Rheumatology

Rheumatology covers all systemic autoimmune rheumatic diseases (SARD) that target multiple tissues and/or organs, causing inflammation resulting in rashes, pain, discomfort and even death.

The major targets of SARDs are, for instance, connective tissue, joints, muscles and blood vessels. After a first screen for antinuclear antibodies, ANA-LIA, ANA-LIA XL and quantitative ELISAs provide a basis to identify the specific SARD.

Line Immunoassay Solutions Flyer (PDF, 2.33 MiB)
Line Immunoassays Flyer (PDF, 1.61 MiB)
ANA-LIA-XL Fact Sheet (PDF, 1.4 MiB)
ARTHRITIS-LIA-XL Fact Sheet (PDF, 0.24 MiB)
Rheumatoid Arthritis Flyer (PDF, 4.9 MiB)
Antiphospholipid Syndrome Flyer (PDF, 0.57 MiB)
Antiphospholipid Syndrome (fetal loss) Flyer (PDF, 0.57 MiB)
Immune Complex Detection Flyer (PDF, 1.22 MiB)
Anti-Salmonella ELISA Flyer (PDF, 0.22 MiB)
anti DFS70 antibodies - Whitepaper (PDF, 0.16 MiB)
Vasculitis Flyer (PDF, 2.12 MiB)
RA33 - Whitepaper (PDF, 0.14 MiB)
CTD
SLE

ANA-LIA XL (Line Immunoassay)

Qualitative determination of anti-nuclear IgG antibodies. Internal function and cut-off control
Kit name Format Antigens Size REF
ANA-LIA XL IgG dsDNA, Nucleosome, Histone, SmD1, PCNA, P0, SS-A/Ro 60, SS-A/Ro 52, SS-B/La, CENP-B, Scl70, U1-snRNP, AMA M2, Jo-1, PMScl100, Mi-2 and Ku 70/80, DFS70 24 tests ITC92007
SLE

Anti-C1q-Antibodies (ELISA)

Quantitative determination of IgG autoantibodies to complement C1q.
Calibration: 12.5 / 25 / 50 / 100 / 200 U/ml Cut-off: 20 U/ml

Kit name Format Antigens Size REF
Anti-C1q-Antibodies IgG C1q 96 tests ITC59033
RA/JIA

Arthitis-LIA (Line Immunoassay)

Qualitative determination of rheumatoid arthritis antibodies Internal function and cut-off control
Kit name Format Antigens Size REF
Arthritis-LIA IgG/ RF-IgM RF-IgM, ACPA (CP4), RA33, dsDNA, SS-A/Ro60, SS-A/ Ro52, SS-B/La 24 tests ITC94000
CTD
SLE

ANA-LIA (Line Immunoassay)

Qualitative determination of anti-nuclear IgG antibodies. Internal function and cut-off control
Kit name Format Antigens Size REF
ANA-LIA IgG

Nucleosome, dsDNA, Histone, SmD1, U1-snRNP, SS-A/Ro 60, SS-A/Ro 52,
SS-B/La, Scl70, CENP-B, Jo-1, RPP/P0 and P0

 24 tests ITC92000
APS

Annexin V-Antibodies (ELISA)

Quantitative determination of IgG / IgA / IgM antibodies to annexin V.
Calibration:6.25 / 12.5 / 25 / 50 / 100 U/ml Cut-off: 25 U/ml

Kit name Format Antigens Size REF
Annexin V-Antibodies Screen IgG / IgA / IgM Annexin V 96 tests ITC59550
CTD
RA/JIA

ANA Screen (ELISA)

Quantitative and qualitative determination of antibodies to anti-nuclear antigens.
Kit name Format Antigens Size REF
ANA Screen IgG / IgA / IgM HeLa cell nuclei, dsDNA, Nucleosome, Histone, SS-A/Ro, SS-B/La, CENP-B, Jo-1 96 tests ITC60001
ANA Screen (cut-off) IgG / IgA / IgM HeLa cell nuclei, dsDNA, Nucleosome, Histone, SS-A/Ro, SS-B/La, CENP-B, Jo-1 96 tests ITC70001
APS
SLE

β2-Glycoprotein 1-Antibodies (ELISA)

Determination of antibodies to ß2-Glycoprotein 1

Kit name Format Antigens Size REF
beta2-Glycoprotein 1-Antibodies IgG IgG ß2GP1 96 tests ITC59150
beta2-Glycoprotein 1-Antibodies Screen IgG / IgA / IgM ß2GP1 96 tests ITC59050
beta2-Glycoprotein 1-Antibodies IgM IgM ß2GP1 96 tests ITC59250
APS
RA/JIA
SLE

Cardiolipin-Antibodies (ELISA)

Determination of antibodies to cardiolipin
Kit name Format Antigens Size REF
Cardiolipin-Antibodies Screen IgG / IgA / IgM Cardiolipin + cofactor ß2GP1 96 tests ITC59076
Cardiolipin-Antibodies Combi IgG /IgM Cardiolipin + cofactor β2GP1 96 tests ITC59082
Cardiolipin-Antibodies IgG IgG Cardiolipin + cofactor β2GP1 96 tests ITC59071
Cardiolipin-Antibodies IgM IgM Cardiolipin + cofactor β2GP1 96 tests ITC59081
CIC

C3d-CIC (ELISA)

Quantitative determination of C3d containing circulating immune complexes of IgG
Kit name Format Antigens Size REF
C3d-CIC IgG Anti-C3d-CIC 96 tests ITC59032
CIC

CIC IgG (ELISA)

Quantitative determination of circulating immune complexes containing IgG by C1q binding
Kit name Format Antigens Size REF
CIC IgG IgG C1q-CIC 96 tests ITC59031
RA/JIA

CCP-Antibodies (ELISA)

Quantitative / qualitative determination of IgG antibodies to cyclic citrullinated peptide.
Calibration: 25 / 50 / 200 / 800 / 1600 U/ml Cut-off: 25 U/ml

Kit name Format Antigens Size REF
CCP-Antibodies IgG CCP2 96 tests ITC60021
CIC

Complement Activity (ELISA)

Quantitative determination of complement activity.
Kit name Format Antigens Size REF
Complement Activity IgG IgM (complement activator) 96 tests ITC59035
SLE

dsDNA-Antibodies (ELISA)

Quantitative determination of IgG antibodies to double-stranded DNA.
Calibration: Quantitative, 12.5 / 25 / 50 / 100 / 200 IU/ml Cut-off: 25 U/ml

Kit name Format Antigens Size REF
dsDNA-Antibodies IgG Double-stranded DNA 96 tests ITC59001
CTD
SLE

ENA-Profile (ELISA)

Simultaneously qualitative determination of IgG antibodies to extractable nuclear antigens.
Cut-off control and cut-off calibrator

Kit name Format Antigens Size REF
ENA-Profile IgG SS-A/Ro, SS-B/La, SmD1, U1-snRNP, Histone, CENP-B, Scl70, Jo-1 96 tests ITC60033
CTD
SLE

ENA Screen (ELISA)

Qualitative determination of IgG antibodies to extractable nuclear antigens. Cut-off calibrator
Kit name Format Antigens Size REF
ENA Screen (cut-off) IgG SS-A/Ro, SS-B/La, SmD1, CENP-B, Jo-1, U1-snRNP, Scl70, Histone, Centromere B 96 tests ITC70005
VAS

GBM-Antibodies (ELISA)

Quantitative determination of IgG antibodies to glomerular basement membrane.
Calibration: 2.5 / 7.4 / 22.2 / 66.7 / 200 U/ml Cut-off: 10 U/ml

Kit name Format Antigens Size REF
GBM-Antibodies IgG GBM 96 tests ITC82070
RA/JIA
ReA
SLE

HumaTex (Rapid Tests)

Latex slide test for non-diluted serum.
Kit name Format Antigens Size REF
HumaTex CRP Complete kit 100 tests 40043
HumaTex CRP Latex reagent 100 tests 40040
HumaTex RF Complete kit 100 tests 40053
HumaTex RF Latex reagent 100 tests 40050
HumaTex ASO Complete kit 100 tests 40063
CTD

Jo-1-Antibodies (ELISA)

Quantitative / qualitative determination of IgG antibodies to Jo-1.
Calibration: 12.5 / 25 / 50 / 100 / 200 U/ml Cut-off: 25 U/ml

Kit name Format Antigens Size REF
Jo-1-Antibodies IgG Jo-1 96 tests ITC70025
CTD

Myositis-LIA PL (Line Immunoassay)

Qualitative determination of myositis IgG antibodies. Internal function and cut-off control
Kit name Format Antigens Size REF
Myositis-LIA PL IgG Jo-1, Mi-2, PM-Scl100, U1-snRNP, Ku 70/80, PL-7, PL-12 24 tests ITC60201
VAS

MPO-ANCA (ELISA)

Quantitative determination of IgG antibodies to myeloperoxidase.
Calibration: 2.5 / 7.4 / 22.2 / 66.7 / 200 U/ml Cut-off: 10 U/ml

Kit name Format Antigens Size REF
MPO-ANCA IgG Myeloperoxidase 96 tests ITC82030
SLE

Nucleosome-Antibodies (ELISA)

Quantitative determination of IgG antibodies to nucleosomes.
Calibration: 12.5 / 25 / 50 / 100 / 200 U/ml Cut-off: 25 U/ml

Kit name Format Antigens Size REF
Nucleosome-Antibodies IgG Nucleosomes 96 tests ITC59002
APS

oxLDL-Antibodies Ig(GM) (ELISA)

Quantitative determination of IgG / IgM antibodies to oxidized low-density lipoproteins.
Calibration: 12.5 / 25 / 50 / 100 / 200 U/ml Cut-off: 30 U/ml

Kit name Format Antigens Size REF
oxLDL-Antibodies IgG / IgM oxLDL 96 tests ITC59500
APS

Phospholipid-Antibodies (ELISA)

Quantitative determination of IgG / IgM antibodies to phospholipids.
Calibration: 6 / 12.5 / 25 / 50 / 100 U/ml Cut-off: 15-25 U/ml

Kit name Format Antigens Size REF
Phospholipid-Antibodies Screen IgG / IgM

Cardiolipin, Beta-2-GP1, Phosphatidylserine, Phosphatidylethanolamine, Phosphatidic acid, phosphatidylinositol

 96 tests ITC59070
APS

Phosphatidylserine-Antibodies (ELISA)

Determination of antibodies to phosphatidylserine
Kit name Format Antigens Size REF
Phosphatidylserine-Antibodies Screen IgG / IgA / IgM

Phosphatidylserine + cofactor β2GP1

 96 tests ITC59027
Phosphatidylserine-Antibodies IgG IgG

Phosphatidylserine + cofactor β2GP1

 96 tests ITC59011
Phosphatidylserine-Antibodies IgM IgM

Phosphatidylserine + cofactor β2GP1

 96 tests ITC59021
VAS

PR3-ANCA (ELISA)

Quantitative determination of IgG antibodies to proteinase 3.
Calibration: 2.5 / 7.4 / 22.2 / 66.7 / 200 U/ml Cut-off: 10 U/ml

Kit name Format Antigens Size REF
PR3-ANCA IgG Proteinase 3 96 tests ITC82020
APS

Phosphatidylethanolamine-Antibodies (ELISA)

Quantitative determination of IgG / IgA / IgM antibodies to phosphatidylethanolamine.
Calibration: 6.25 / 12.5 / 25 / 50 / 100 U/ml Cut-off: 15 U/ml

Kit name Format Antigens Size REF
Phosphatidylethanolamine-Antibodies Screen IgG / IgA / IgM Phosphatidylethanolamine 96 tests ITC59400
APS

Prothrombin-Antibodies (ELISA)

Quantitative determination of IgG / IgA / IgM antibodies to prothrombin.
Calibration: 6.25 / 12.5 / 25 / 50 / 100 U/ml Cut-off: 30 U/ml

Kit name Format Antigens Size REF
Prothrombin-Antibodies Screen IgG / IgA / IgM Prothrombin (factor II), Phosphatidylserine 96 tests ITC59450
RA/JIA

RF IgM (ELISA)

Quantitative determination of IgM antibodies to rheumatoid factor.
Calibration: 12.5 / 25 / 50 / 100 / 200 U/ml Cut-off: 15 IU/ml

Kit name Format Antigens Size REF
RF IgM IgG Rabbit IgG 96 tests ITC60003
RA/JIA

RA33-Antibodies (ELISA)

Quantitative determination of IgG antibodies to RA33.
Calibration: 12.5 / 25 / 50 / 100 / 200 U/ml Cut-off: 25 U/ml

Kit name Format Antigens Size REF
RA33-Antibodies IgG RA33 96 tests ITC60015
CTD
SLE

SS-A/Ro-Antibodies (ELISA)

Quantitative / qualitative determination of IgG antibodies to SS-A/Ro.
Calibration: 12.5 / 25 / 50 / 100 / 200 U/ml Cut-off: 25 U/ml

Kit name Format Antigens Size REF
SS-A/Ro-Antibodies IgG SS-A/Ro 60, SS-A/Ro 52 96 tests ITC70026
CTD
SLE

SS-B/La-Antibodies (ELISA)

Quantitative / qualitative determination of IgG antibodies to SS-B/La.
Calibration: 12.5 / 25 / 50 / 100 / 200 U/ml Cut-off: 25 U/ml

Kit name Format Antigens Size REF
SS-B/La-Antibodies IgG SS-B/La 96 tests ITC70024
CTD

ScI70-Antibodies (ELISA)

Quantitative / qualitative determination of IgG antibodies to Scl70.
Calibration: 12.5/25/50/100/200 U/ml Cut-off: 25 U/ml

Kit name Format Antigens Size REF
ScI70-Antibodies IgG Scl70 96 tests ITC70028
SLE

SmD1-Antibodies IgG (ELISA)

Quantitative / qualitative determination of IgG antibodies to SmD.
Calibration: 12.5 /25 / 50 / 100 / 200 U/ml Cut-off: 25 U/ml

Kit name Format Antigens Size REF
SmD1-Antibodies IgG IgG SmD1-peptide 96 tests ITC60029
ReA

Salmonella (ELISA)

Qualitative determination of antibodies to salmonella.
Kit name Format Antigens Size REF
Salmonella-Antibodies Screen (cut-off) IgG / IgA / IgM LPS of S. typhimurium and S. enteritidis 96 tests ITC40040
Salmonella-Antibodies IgA (cut-off) IgA LPS of S. typhimurium and S. enteritidis 96 tests ITC40050
SLE

SLE (Rapid Tests)

Latex slide test for serum.
Kit name Format Antigens Size REF
SLE Latex Test Complete kit 50 tests 40030
CTD
SLE

U1-snRNP-Antibodies (ELISA)

Quantitative / qualitative determination of IgG antibodies to U1-snRNP. Calibration: 12.5/25/50/100/200 U/ml Cut-off: 25 U/ml
Kit name Format Antigens Size REF
U1-snRNP-Antibodies IgG U1-snRNP 96 tests ITC70022
VAS

Vasculitis-LIA (Line Immunoassay)

Qualitative determination of vasculitis IgG antibodies. Internal function and cut-off control
Kit name Format Antigens Size REF
Vasculitis-LIA IgG PR3, MPO and GBM 24 tests ITC82040
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